LU MF Farmakoloģijas katedras pētnieki piedalās vairākos nacionālas nozīmes un starptautiskos projektos, kas ir vērsti uz neiroloģisko saslimšanu (šizofrēnijas, Alcheimera, Pārkinsona slimības un insulta) mehānismu izpēti, kas nākotnē palīdzētu izstrādāt jaunas ārstēšanas stratēģijas.

Aktuālie projekti

  • Projekta līguma numurs: ES RTD/2020/26
  • Projekta koordinators: Prof. Jens Pahnke (NO)
  • Projekta partneri: Oliver Langer (AT), Peter Brust (DE), Fabien Gosselet (FR), Baiba Jansone (LV, zinātniskā vadītāja), Laureta Buševica (LV, administratīvā koordinatore), Ondřej Soukup (CZ), Henrik Biverstål (SE)
  • Projekta īstenošanas laiks: 2021-2024.

Detalizēta informācija 
Projekta kopsavilkums JPND vietnē 

  • Projekta numurs: 1.1.1.2/VIAA/4/20/626
  • Projekta vadītājs: Vladimirs Piļipenko
  • Projekta īstenošanas laiks: 2020-2023

Detalizēta informācija

Projekta ietvaros notiks mikrogliālās aktivācijas lomas izpēte komplementa C4-stratificētos šizofrēnijas pacientos un peļu C4 pārmērīgas ekspresijas modelī.

  • Projekta numurs: 1.1.1.5/ERANET/20/01
  • Konsorcija koordinators: Ryad Tamouza (FR)
  • Konsorcija partneru projektu dalībvalstu vadītāji: Benoît Zuber (CH) Corentin Le Magueresse (FR) Martin Fuhrmann (DE) un Baiba Jansone (LV)
  • Projekta īstenošanas laiks: 2020-2022

Detalizēta informācija 
Projekta kopsavilkums NEURON vietnē 

  • Projekta numurs: lzp-2018/1-0275
  • Projekta zinātniskā vadītāja: Baiba Jansone
  • Projekta īstenošanas laiks: 2018-2021.

Detalizēta informācija

Projekta ietvaros notiks daudzpakāpju sinaptiskās disfunkcijas izpēte insulta modeļos.

  • Projekta numurs: ES RTD/2018/29
  • Konsorcija koordinators: Valentin U. Nägerl (FR)
  • Konsorcija partneru projektu dalībvalstu vadītāji: Nikolaus Plesnila (DE), Jérôme Badaut (FR), Leszek Kaczmarek (PL), Javier Defelipe (ES) un Baiba Jansone (LV)
  • Projekta īstenošanas laiks: 2018-2021.

Detalizēta informācija
Projekta kopsavilkums NEURON vietnē 

  • Projekta numurs: Y5-AZ114-ZF-N-840
  • Projekta galvenie mērķi:
    • Dabas vielu un to sintētisko analogu farmakoloģisko īpašību pētījumi
      Atrast jauna tipa farmakoloģiskas darbības dabas vielas vai to analogus ar inovatīvām farmakoloģiskajām īpašībām
    • Dabas vielu analogu sintēze un analīze
      Veikt dabas vielu analogu sintēzi un izstrādāt analīzes metodes.
  • Projekta īstenošanas laiks: 2017-2020
  • Publikācijas:
    • Vanaga I, Gubernator J, Nakurte I, Kletnieks U, Muceniece R, Jansone B. Identification of Abies sibirica L. polyprenols and characterisation of polyprenol-containing liposomes. Molecules  2020, v25, issue 8, No 25081801.
    • Dzirkale Z, Nakurte I, Jekabsons K, Muceniece R, Klusa V. Intra-Nasally Administered Oligopeptide Lunasin Acts as a Possible Anti-Psychotic Agent in Mice Models. Medicina (Kaunas). 2019 Jul 21;55(7):393. doi: 10.3390/medicina55070393. PMID: 31330913
    • Muceniece R, Namniece J, Nakurte I, Jekabsons K, Riekstina U, Jansone B. Pharmacological research on natural substances in Latvia: Focus on lunasin, betulin, polyprenol and phlorizin. Pharmacol Res. 2016 Nov;113(Pt B):760-770. doi: 10.1016/j.phrs.2016.03.040. Epub 2016 Apr 21. Review. PubMed PMID: 27109319.
    • Jansone, B., Dzirkale, Z., Jekabsons, K.,Pilipenko V., Beitnere U., Magure I., Skumbins R., Kletnieks U., Vanaga I., Muceniece, R., Kluša, V. Spruce needle polyprenols protect against atorvastatin-induced muscle weakness and do not influence central nervous system functions in rats. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 2016, 70(1), pp. 13-20.

Īstenotie projekti

SIA "Mikrotīkls" finansēts un Latvijas Universitātes fonda administrēts projekts "Vai ar antidiabētisko vielu metformīnu var apstādināt Alcheimera slimību pirms tā sākusies?"


EEZ un Norvēģijas finanšu instrumenta projekts “Dažādu beta-amiloīda peptīdu sekvenču efekti: fokuss uz īso peptīdu pielietojuma iespējām demences terapijā”.

  • Projekta numurs: NFI/R/2014/023
  • Projekta vadītājs: Baiba Jansone
  • Projekta īstenošanas laiks: 2015-2017


ERAF finansētais projekts “Hronisku brūču dzīšanu veicinošas medicīnas ierīces
izstrāde”

  • Projekta numurs: 2DP/2.1.1.1.0/14/APIA/VIAA/046
  • Projekta izpildītāji MF: Baiba Jansone, Zane Dzirkale
  • Projekta īstenošanas laiks: 2014-2015


EEZ un Norvēģijas finanšu instrumenta stipendiju projekts “Enhancing human capital and knowledge in health science by institutional cooperation and mobility between the University of Latvia and three Norwegian universities”

  • Projekta numurs: EEZ/NFI/S/2015/019
  • Projekta koordinators ar Oslo Universitāti: Baiba Jansone
  • Projekta īstenošanas laiks: 2015-2016


EEZ un Norvēģijas finanšu instrumenta stipendiju projekts “Pētniecība un stipendijas” divpusējās sadarbības fonda sagatavošanas vizīšu projekta ieviešana”

  • Projekta numurs: NOR-S-PV2014/008
  • Projekta koordinators ar Oslo Universitāti: Baiba Jansone
  • Projekta īstenošanas laiks: 2015


LU finansēts projekts “Mirstības izpēte dažāda vecuma pacientu grupās un jaunu struktūru izpēte neirodeģeneratīvo saslimšanu ārstēšanā”

  • LU projekta numurs: ZD2014/AZ78
  • Projekta vadītājs: Ingrīda Rumba-Rozenfelde
  • Projekta realizācijas termiņš: 2014-2015

“Pharma and Chemistry Competence Centre of Latvia finansētais projekts “Egles skuju izoprēnspirtu bioloģiskās darbības pētījumi slimību patoloģiju modeļos”

  • Projekta numurs: KC/2.1.2.1.1/10/01/006
  • Projekta realizācijas termiņš: 2013.-2014.
     

LZP finansēts projekts “Multiheterociklu ķīmijas attīstīšana jaunu bioloģiski aktīvu vielu iegūšanai”

  • Projekta numurs: 10.0030
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2009.-2013.
     

Eiropas Sociālā fonda (ESF) finansēts projekts “Neiroimūnās regulācijas iespējas neirodeģeneratīvo slimību ārstēšanā ar jauna tipa priviliģētām struktūrām”

  • Projekta numurs: 2009/0217/1DP/1.1.1.2.0/09/APIA/VIAA/031
  • Projekta vadītāja: Baiba Jansone
  • Projekta realizācijas termiņš: 2010.-2012.


LU finansēts projekts “Neirogliālās šūnas kā neiroprotektīvo vielu darbības mērķis”

  • Projekta numurs: LU-2009/ZP-94
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš 2009.-2012.


LZP finansēts projekts “Uz mitohondrijiem mērķētu mazo molekulu reģeneratīvie efekti neirodeģenerācijas modeļos”

  • Projekta numurs: Z-6173-840
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2009.-2012.

LU finansēts projekts “Uz mitohondrijiem mērķētās farmakoterapijas efektivitāte multiplās sklerozes modelī”

  • Projekta numurs: 2008/ZP-28
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš 2007.-2008.
     

A/S “Olainfarm” un LU pētniecības projekts “Neiromidīna pētījumi diabēta neiropātijas modelī žurkām”

  • Projekta numurs: 2008/2467
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2008.


LZP finansēts projekts “Jaunas stratēģijas anti-HIV terapijas izraisīto neiro- un kardiomiopātiju protekcijā”

  • Projekta numurs: 05.1418
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2005.-2008.
     

EU COST projekts “Targeting of taurine and its analogues to protect against oxidative stress”

  • Projekta numurs: D34
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2005.-2008.
     

EU COST projekts “Design for Sustainable and/or Green Biologically Important Agents”

  • Projekta numurs: D29
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2004.-2007.


A/S „Grindeks” un LU Pētniecības projekts “Mildronāta terapeitiskās/protektīvas aktivitātes novērtējums dažādu klašu anti-HIV preparātu kardio-, neiro- un hepatotoksicitātes modeļos”

  • Projekta numurs: 2362
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2007.


A/S „Grindeks” un LU Pētniecības projekts “Cerebrokrasta jauno analogu neiroprotektīvās aktivitātes pētījumi in vivo”

  • Projekta numurs: 2376
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2007.


A/S „Grindeks” un LU Pētniecības projekts “Mildronāta terapeitiskās efektivitātes noteikšana stavudīna izraisīto perifēro neiropātiju modelī žurkām”

  • Projekta numurs: 2377
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2007.


Sadarbības līgums starp A/S „Grindeks”, LU un Latvijas Organiskās sintēzes institūtu “Mildronāta protektīvie efekti anti-HIV terapijas izraisītajās kardio- un neiropātijās”

  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2006.


LU finansēts projekts “Stresa izraisītie neiroķīmisko procesu traucējumi un to protekcijas/reversijas iespējas: mitohondriji kā mērķis”

  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2006.

LU finansēts projekts “Atkarību izraisošo vielu melanokortīnerģisko signālmehānismu pētījumi”

  • Projekta numurs: 2005/7-LU
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2004.-2005.


EU projekts “MedNatNet”

  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2003.-2004.


EU COST projekts “Novel Peptidomimetic Type Substances with Neuroprotective Properties”

  • Projekta numurs: D13
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2001.-2004.


Howard Hughes Medical Institute finansēts projekts “Pharmacological Studies on Melanocortin Receptor Subtypes”

  • Projekta numurs: 75195-542601
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 1995.-2000


LZP finansētais projekts “Melanokortīnu kā vielu atkarības regulātoru izraisītie neiroķīmiskie un uzvedības procesi”

  • Projekta numurs: 01.0037
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2001.-2004.


LU Zinātniskās un tehniskās kooperācijas ar Upsalas Universitāti finansiālās palīdzības grants

  • Projekta numurs: 1874
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 2000.-2002.


LZP finansēts projekts “Aminoskābes saturošu peptidomimētiķu neirotrofās un antineirotoksiskās darbības mehānismu pētījumi”

  • Projekta numurs: 96.698
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 1997.-2000.

EU COPERNICUS pētniecības projekts “Investigation and Elaboration of Novel Chiral Drugs for Biotechnological Procedures”

  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 1995.-1997.


KIRT finansētais projekts “Neuroactive Amino Acid Containing Peptidomimetics: Focus in the Neurotransmitter Mechanisms”

  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 1995.-1996.
     

LZP finansēts projekts “Jauna tipa kognitīvo funkciju stimulējošas vielas: uzvedības un intracelulāro procesu pētījumi”

  • Projekta numurs: 93.439
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 1994.-1996.


KIRT finansēts projekts “Peptide-mimicking Substances: Role of the “Free” and “Crypto” Amino Acids in Memory Improving Activity”

  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 1994.


LZP finansētais projekts “Nervu un miokarda šūnu funkcionālo mehānismu pētījumi hipoksijas, stresa, novecošanās un citos aversīvos apstakļos un attiecīgo endogēno un eksogēno korektoru meklējumi”

  • Projekta numurs: 90.428
  • Projekta vadītājs: Vija Kluša
  • Projekta realizācijas termiņš: 1991.-1993.

Publikācijas

Farmakoloģijas katedras darbinieku pētījumu rezultāti tiek publicēti starptautiski citējamos žurnālos neirozinātnē, tostarp arī augstas raudzes žurnālos ar Q1 radītāju, piemēram, Basic Clinical Pharmacology and Toxicology (H=80), BMC Neuroscience (H=86), European Journal of Pharmacology (H=167), Neuropharmacology (H=150), Pharmacological Research (H=118), PLoS ONE (H=268).

2020. gadā Farmakoloģijas katedras pētnieku raksti publicēti starptautiski citējamos zinātniskos žurnālos:

  • Katja Stefan, Lionel Yi Wen Leck, Vigneshwaran Namasivayam, Pablo Bascunana, Michael Li-Hsuan Huang, Patrick Johannes Riss, Jens Pahnke, Patric Jan Jansson, Sven Marcel Stefan. Vesicular ATP-binding cassette transporters in human disease – relevant aspects of their organization for future drug development. Future drugs discoveries. 29 September 2020, 10.4155/fdd-2020-0025 
  • Jolanta Upīte, Inga Kadish, Thomas van Groen, Baiba Jansone (2020) Subchronic administration of auranofin reduced amyloid-β plaque pathology in a transgenic APPNL-G-F/NL-G-F mouse model. Brain Research, Vol. 1746, 147022. https://doi.org/10.1016/j.brainres.2020.147022
  • Vanaga I, Gubernator  J, Nakurte I, Kletnieks U, Muceniece U, Jansone B. (2020) Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes. Molecules, Vol. 25, N 8, Article number 1801, p.1-13, https://doi.org/10.3390/molecules25081801 , URL: https://www.mdpi.com/1420-3049/25/8/1801/htm
  • Vladimirs Pilipenko, Karīna Narbute, Jolanta Pupure, Ilva Kristiāna Langrate, Ruta Muceniece, Vija Kluša. Neuroprotective potential of antihyperglycemic drug metformin in streptozocin-induced rat model of sporadic Alzheimer's disease. European Journal of Pharmacology, Volume 881, 2020 June, 173290, https://doi.org/10.1016/j.ejphar.2020.173290 
  • Narbute K, Pilipenko V, Pupure J, Klinovičs T, Auders J, Jonavičė U, Kriaučiūnaitė K, Pivoriūnas A, Kluša V. Time-Dependent Memory and Gait Improvement by Intranasally-Administered Extracellular Vesicles in Parkinson's Disease Model Rats. Cell Mol Neurobiol. 2020 May 14. doi: 10.1007/s10571-020-00865-8. Online ahead of print. PMID: 32410106  
  • Borovkova M., Bykov A., Popov A.,  Pierangelo A., Novikova T., Pahnke J., Meglinski I. Evaluatingβ-amyloidosis progression in Alzheimer’s disease with Mueller polarimetry. Vol. 11, No. 8 /1 August 2020 /Biomedical Optics Express4509
  • Pablo Bascuñana, Luisa Möhle, Mirjam Brackhan, Jens Pahnke. Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis. Drugs in R&D, published online: 22 July, 2020; https://doi.org/10.1007/s40268-020-00316-1
  • Surya Prakash Rai, Markus Krohn and Jens Pahnke. Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer’s Disease Mice. Journal of Alzheimer’s Disease 75 (2020) 1301–1317. DOI 10.3233/JAD-200161
  • Mariia Borovkova, Alexander Bykov, Alexey Popov, Angelo Pierangelo, Tatiana Novikova, Jens Pahnke, Igor Meglinski. The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer’s disease. Proc. SPIE 11234, Optical Biopsy XVIII: Toward RealTime Spectroscopic Imaging and Diagnosis, 112340M (21 February 2020); https://doi.org/10.1117/12.2550795
  • Axel Abelein, Gefei Chen, Kristīne Kitoka, Rihards Aleksis, Filips Oleskovs, Médoune Sarr, Michael Landreh, Jens Pahnke, Kerstin Nordling, Nina Kronqvist, Kristaps Jaudzems, Anna Rising, Jan Johansson & Henrik Biverstål. High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain. Scientific Reports volume 10, Article number: 235 (2020). DOI: 10.1038/s41598-019-57143-x.
  • Zoufal V, Wanek T, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Bauer M, Pahnke J, Langer O. Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET. J Cereb Blood Flow Metab. (2020) 40:150-162. doi: 10.1177/0271678X18806640.
  • Narbute K, Pilipenko V, Pupure J, Dzirkale Z, Jonavičė U, Tunaitis V, Jansone B, Klusa V, Pivoriūnas A. Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats. Stem Cells Transl Med, 2019, 8(5), 490-9. https://doi.org/10.1002/sctm.18-0162
  • Pilipenko V, Narbute K, Amara I, Trovato A, Polimeni A, Pupure J, Poikans J, Bisenieks J, Calabrese V, Jansone B, Klusa V. GABA-containing compound gammapyrone protects against brain impairments in Alzheimer's disease model male rats and prevents mitochondrial dysfunction in cell culture. J Neurosci Res, 2019, 97(6), 708-26. https://doi.org/10.1002/jnr.24396
  • Pilipenko V, Narbute K, Pupure J, Rumaks J, Jansone B, Klusa V. Neuroprotective action of diazepam at very low and moderate doses in Alzheimer's disease model rats. Neuropharmacol, 2019, 144, 319-26. https://doi.org/10.1016/j.neuropharm.2018.11.003
  • Pilipenko V, Narbute K, Beitnere U, Rumaks J, Pupure J, Jansone B, Klusa V. Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease. Eur J Pharmacol, 2018, 818, 381-99. https://doi.org/10.1016/j.ejphar.2017.11.012
  • Sike Á, Wengenroth J, Upīte J, Brüning T, Eiriz I, Sántha P, Biverstål H, Jansone B, Haugen HJ, Krohn M, Pahnke J. Improved method for cannula fixation for long-term intracerebral brain infusion. J Neurosci Methods, 2017, 290, 145-50. https://doi.org/10.1016/j.jneumeth.2017.07.026
  • Steffen J, Krohn M, Schwitlick C, Brüning T, Paarmann K, Pietrzik CU, Biverstål H, Jansone B, Langer O, Pahnke J. Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice. Acta Neuropathol Commun, 2017, 5, 49. https://doi.org/10.1186/s40478-017-0448-2
  • Velena A, Zarkovic N, Klusa V, Klimaviciusa L, Pupure J, Vigante B, Duburs G. 1,4-Dihydropyridines as tools for mitochondrial medicine against oxidative stress and associated metabolic disorders. Curr Org Chem, 2017, 21(20), 2030-43. https://doi.org/10.1186/s40478-017-0448-2
  • Jansone B, Kadish I, van Groen T, Beitnere U, Plotniece A, Pajuste K, Klusa V. Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer’s disease transgenic female mice. Pharmacol Res, 2016, 113 (Pt B): 781-7. https://doi.org/10.1016/j.phrs.2016.06.020
  • Jansone B, Kuum M, Maciulaitis R. Introductory letter from the Presidents of the Latvian, Estonian and Lithuanian Societies of Pharmacology. Pharmacol Res, 2016, 113 (Pt B):721-2. http://doi.org/10.1016/j.phrs.2016.06.006
  • Jansone B, Kuum M, Maciulaitis R. Pharmacology in Estonia, Latvia and Lithuania: From historical roots to nowadays achievements. Pharmacol Res, 2016, 113 (Pt B):723-30. https://doi.org/10.1016/j.phrs.2016.04.024
  • Jansone B, Dzirkale Z, Jekabsons K, Pilipenko V, Beitnere U, Kletnieks U, Vanaga I, Muceniece R, Klusa V. Influence of spruce needle polyprenols on rat behavior and muscle tone altered by atorvastatin. Proc Latv Acad Sci, 2016, Sect B, 70(1).
  • Muceniece R, Namniece J, Nakurte I, Jekabsons K, Riekstina U, Jansone B. Pharmacological research on natural substances in Latvia: Focus on lunasin, betulin, polyprenol and phlorizin. Pharmacol Res, 2016, 113(Pt B), 760-70. https://doi.org/10.1016/j.phrs.2016.03.040
  • Jansone B, Kadish I, van Groen T, Beitnere U, Moore DR, Plotniece A, Pajuste K, Klusa V. A novel 1,4­-dihydropyridine derivative with memory ­improving activity in wild type and transgenic APPSweDI mice. Plos ONE, 2015, 10(6), e0127686. https://dx.doi.org/10.1371%2Fjournal.pone.0127686 
  • Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O. Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography. J Cereb Blood Flow Metab. (2019) Jun 13:271678X19854541. doi: 10.1177/0271678X19854541.
  • K Paarmanna, SR Prakash, M Krohn, L Möhle, M Brackhan, T Brüning, I Eiriz, J Pahnke. French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer's disease mice. Phytomedicine  (2019) 57:39-48. DOI: 10.1016/j.phymed.2018.11.033
  • Krohn M, Zoufal V, Mairinger S, Wanek T, Paarmann K, Brüning T, Eiriz I, Brackhan M, Langer O, Pahnke J. Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1flx/flx ) with Knockout Capability. Mol Pharmacol. (2019) 96:138-147. doi: 10.1124/mol.119.115824.
  • Ceafalan LC, Fertig TE, Gheorghe TC, Hinescu ME, Popescu BO, Pahnke J, Gherghiceanu M. Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier. J Cell Mol Med. (2019) 23:819-827. doi: 10.1111/jcmm.13980.
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  • Kluša V, Rumaks J, Karajeva N. Neuromidin attenuates neuropathic pain in the streptozocin ­induced diabetes model in rats. Proc Latv Acad Sci, 2008, Sect B, 62, 3(656), 20–30.
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  • Krauze A, Vitoliņa R, Garaliene V, Sīle L, Kluša V, Duburs G. 3,4-trans-4-Aryl-3-(1-pyridinio)-1,2,3,4-tetrahydropyridine-6-thiolates--new group of potential cardiotonic drugs. Eur J Med Chem, 2005, 40(11), 1163­-7. https://doi.org/10.1016/j.ejmech.2005.04.004
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